Mird237 2021 [updated] May 2026
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2.1. Radiation Fundamentals
- Types of radiation (alpha, beta, gamma, neutron)
- Interaction mechanisms (photoelectric effect, Compton scattering, pair production)
- Attenuation coefficients and half-value layer (HVL)
2. Updated Nuclear Decay Data
The 2021 revision uses ICRP 107 and NuDat 3.0 decay data. For common therapeutic radionuclides, this impacted: Types of radiation (alpha, beta, gamma, neutron) Interaction
- Lu-177: Improved beta minus spectra branching ratios.
- I-131: More accurate gamma and conversion electron yields.
- Ac-225: Revised alpha emission probabilities (critical for targeted alpha therapy).
Part 1: The Legacy – What Was MIRD Before 2021?
To appreciate the 2021 revision, we must first understand its predecessor. The original MIRD schema (often referred to as MIRDOSE or OLINDA/PC) relied on radiation transport data from 1999 – primarily based on Cristy and Eckerman’s phantom work.
Key limitations of pre-2021 versions:
- Outdated Anatomical Models: The stylized (geometric) phantoms of the 1970s-1990s did not accurately represent modern patient morphometry.
- Fixed Organ Masses: They assumed “Reference Man” (70 kg, 170 cm) and “Reference Woman” (58 kg, 160 cm), ignoring obesity, cachexia, or pediatric variations.
- Limited Particle Tracking: Older transport codes simplified electron and photon interactions in heterogeneous tissues.
The result was systematic errors in absorbed dose calculations—sometimes exceeding 30% for non-reference individuals.